[17] Queretaro 2-3 Santos Laguna [12] 2021-10-30 22:00
Stadium: Estadio La Corregidora Round: 16
Referee: Jorge Antonio Perez Duran Home Manager: Leonardo Ramos Away Manager: Guillermo Almada
Head to Head
| Mexico - Liga MX | 2021/05/09 02:15 | Santos Laguna v Queretaro | L | 5-0 |
| Mexico - Liga MX | 2021/04/12 00:00 | Queretaro v Santos Laguna | W | 1-0 |
| Mexico - Liga MX | 2020/08/31 00:06 | Santos Laguna v Queretaro | L | 2-1 |
| Mexico - Liga MX | 2019/10/30 01:00 | Santos Laguna v Queretaro | L | 1-0 |
| Mexico - Liga MX | 2019/04/21 23:06 | Santos Laguna v Queretaro | L | 2-1 |
| Mexico - Liga MX | 2018/11/04 22:00 | Queretaro v Santos Laguna | W | 2-1 |
| Mexico - Liga MX | 2018/04/08 23:00 | Santos Laguna v Queretaro | L | 3-0 |
| Mexico - Cup | 2018/03/14 03:15 | Santos Laguna v Queretaro | L | 1-0 |
| Mexico - Liga MX | 2017/10/21 22:00 | Queretaro v Santos Laguna | L | 1-2 |
| Mexico - Liga MX | 2017/04/02 23:00 | Santos Laguna v Queretaro | L | 1-0 |
| Mexico - Liga MX | 2016/10/01 22:00 | Queretaro v Santos Laguna | D | 1-1 |
| Mexico - Liga MX | 2016/01/30 03:30 | Santos Laguna v Queretaro | L | 2-0 |
| Mexico - Liga MX | 2015/08/12 01:30 | Queretaro v Santos Laguna | L | 1-2 |
| Mexico - Liga MX | 2015/06/01 01:30 | Queretaro v Santos Laguna | W | 3-0 |
| Mexico - Liga MX | 2015/05/29 01:30 | Santos Laguna v Queretaro | L | 5-0 |
| Mexico - Cup | 2015/03/04 03:00 | Santos Laguna v Queretaro | D | 2-2 |
| Mexico - Cup | 2015/02/26 03:00 | Queretaro v Santos Laguna | W | 5-0 |
| Mexico - Liga MX | 2015/01/31 01:30 | Queretaro v Santos Laguna | L | 0-1 |
| Mexico - Liga MX | 2014/08/10 01:00 | Santos Laguna v Queretaro | W | 2-3 |
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