Stadium: Duane Stadium Round: 1
Home Manager: Dan Curran Away Manager: Bob Chesney
| NCAAF | 2021/12/04 00:00 | Holy Cross v Villanova | L | 16-21 |
| NCAAF | 2021/11/27 17:00 | Sacred Heart v Holy Cross | W | 10-13 |
| NCAAF | 2021/11/20 18:00 | Holy Cross v Bucknell | W | 45-6 |
| NCAAF | 2021/11/13 18:00 | Holy Cross v Fordham | W | 52-24 |
| NCAAF | 2021/11/06 16:30 | Lafayette v Holy Cross | W | 10-35 |
| NCAAF | 2021/10/30 16:00 | Holy Cross v Lehigh | W | 31-12 |
| NCAAF | 2021/10/23 21:00 | Colgate v Holy Cross | W | 10-42 |
| NCAAF | 2021/10/16 17:30 | Georgetown v Holy Cross | W | 14-48 |
| NCAAF | 2021/11/20 18:00 | Bryant v Merrimack | L | 58-14 |
| NCAAF | 2021/11/13 17:00 | Merrimack v St.Francis (PA) | L | 6-22 |
| NCAAF | 2021/11/06 16:00 | Merrimack v Wagner | W | 35-26 |
| NCAAF | 2021/10/30 17:00 | Central Connecticut v Merrimack | L | 49-21 |
| NCAAF | 2021/10/16 16:00 | Merrimack v LIU Brooklyn | W | 43-5 |
| NCAAF | 2021/10/09 18:00 | Merrimack v Sacred Heart | L | 10-20 |
| NCAAF | 2021/10/02 17:00 | Duquesne v Merrimack | L | 37-14 |
| NCAAF | 2021/09/25 18:00 | Merrimack v Delaware State | W | 47-10 |