Stadium: Fisher Stadium Round: 1
Home Manager: John Troxell Away Manager: Bob Chesney
| NCAAF | 2021/11/06 16:30 | Lafayette v Holy Cross | W | 10-35 |
| NCAAF | 2019/11/09 17:00 | Lafayette v Holy Cross | L | 23-20 |
| NCAAF FCS | 2018/11/03 16:30 | Holy Cross v Lafayette | W | 40-14 |
| NCAAF | 2017/09/30 17:05 | Holy Cross v Lafayette | L | 7-10 |
| NCAAF | 2022/10/08 20:00 | Bucknell v Holy Cross | W | 0-57 |
| NCAAF | 2022/10/01 17:00 | Holy Cross v Harvard | W | 30-21 |
| NCAAF | 2022/09/24 17:00 | Holy Cross v Colgate | W | 35-10 |
| NCAAF | 2022/09/17 18:00 | Yale v Holy Cross | W | 14-38 |
| NCAAF | 2022/09/10 22:00 | Holy Cross v Buffalo | W | 37-31 |
| NCAAF | 2022/09/02 23:00 | Holy Cross v Merrimack | W | 31-17 |
| NCAAF | 2021/12/04 00:00 | Holy Cross v Villanova | L | 16-21 |
| NCAAF | 2021/11/27 17:00 | Sacred Heart v Holy Cross | W | 10-13 |
| NCAAF | 2022/10/12 23:30 | Lafayette v Marshall | W | 23-13 |
| NCAAF | 2022/10/08 16:30 | Princeton v Lafayette | L | 23-2 |
| NCAAF | 2022/10/01 21:00 | South Alabama v Lafayette | L | 20-17 |
| NCAAF | 2022/10/01 19:30 | Lafayette v Bucknell | W | 24-14 |
| NCAAF | 2022/09/25 00:00 | Lafayette v UL Monroe | L | 17-21 |
| NCAAF | 2022/09/24 17:00 | Lafayette v Pennsylvania | L | 0-12 |
| NCAAF | 2022/09/17 23:30 | Lafayette v Rice | L | 21-33 |
| NCAAF | 2022/09/17 19:30 | William & Mary v Lafayette | L | 34-7 |