[18] Reilly Opelka 6-7,5-7 Casper Ruud [8] 2022-05-20 12:15
Stadium: Center Court Round: 28 Ground: Clay
Head to Head
| Laver Cup | 2021/09/24 17:00 | Casper Ruud v Reilly Opelka | 6-3,7-6 |
| ATP Cincinnati | 2021/08/18 17:25 | Casper Ruud v Reilly Opelka | 6-7,6-0,7-6 |
| ATP Houston | 2019/04/10 23:30 | Reilly Opelka v Casper Ruud | 6-4,4-6,4-6 |
| Australian Open 2017 Qual | 2017/01/14 03:40 | Reilly Opelka v Casper Ruud | 7-6,6-3 |
Home History
| ATP Genéve | 2022/05/19 11:30 | Tallon Griekspoor v Reilly Opelka | 4-6,6-3,3-6 |
| ATP Genéve | 2022/05/18 10:00 | Christopher O'Connell v Reilly Opelka | 3-6,5-7 |
| ATP Roma | 2022/05/09 09:00 | Stan Wawrinka v Reilly Opelka | 3-6,7-5,6-2 |
| ATP Madrid | 2022/05/03 18:20 | Reilly Opelka v Sebastian Korda | 3-6,5-7 |
| ATP München | 2022/04/28 13:30 | Reilly Opelka v Oscar Otte | 6-7,2-6 |
| ATP Houston | 2022/04/10 19:00 | Reilly Opelka v John Isner | 6-3,7-6 |
| ATP Houston | 2022/04/09 18:00 | Nick Kyrgios v Reilly Opelka | 3-6,5-7 |
| ATP Houston | 2022/04/08 17:00 | Reilly Opelka v Gijs Brouwer | 6-3,7-5 |
Away History
| ATP Genéve | 2022/05/19 13:20 | Thanasi Kokkinakis v Casper Ruud | 4-6,6-7 |
| ATP Genéve | 2022/05/18 16:00 | Benoit Paire v Casper Ruud | 3-6,1-6 |
| ATP Roma | 2022/05/14 17:45 | Novak Djokovic v Casper Ruud | 6-4,6-3 |
| ATP Roma | 2022/05/13 13:55 | Denis Shapovalov v Casper Ruud | 6-7,5-7 |
| ATP Roma | 2022/05/12 15:25 | Jenson Brooksby v Casper Ruud | 3-6,4-6 |
| ATP Roma | 2022/05/10 18:50 | Botic Van De Zandschulp v Casper Ruud | 7-6,2-6,4-6 |
| ATP Madrid | 2022/05/04 10:00 | Dusan Lajovic v Casper Ruud | 7-6,2-6,6-4 |
| ATP München | 2022/04/29 11:30 | Botic Van De Zandschulp v Casper Ruud | 7-5,6-1 |
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