[21] John Isner 6-7,6-7 Stefanos Tsitsipas [6] 2020-08-25 21:30
Stadium: Court 10 Round: 26 Ground: Hardcourt indoor
Head to Head
| ATP Beijing | 2019/10/04 08:50 | John Isner v Stefanos Tsitsipas | 6-7,3-6 |
| Wimbledon | 2018/07/09 13:40 | John Isner v Stefanos Tsitsipas | 6-4,7-6,7-6 |
| ATP Shanghai | 2017/10/11 12:20 | Stefanos Tsitsipas v John Isner | 6-7,6-7 |
Home History
| ATP New York | 2020/08/24 17:05 | John Isner v John Millman | 4-6,7-6,7-6 |
| ATP New York | 2020/08/23 19:20 | John Isner v Hubert Hurkacz | 7-5,6-4 |
| All American Team Cup | 2020/07/05 18:20 | John Isner v Christopher Eubanks | 5-7,6-4,6-10 |
| All American Team Cup | 2020/07/04 22:00 | John Isner v Kevin King | 6-1,6-3 |
| All American Team Cup | 2020/07/03 22:00 | John Isner v Taylor Fritz | 6-3,6-4 |
| ATP Acapulco | 2020/02/29 00:05 | Taylor Fritz v John Isner | 2-6,7-5,6-3 |
| ATP Acapulco | 2020/02/27 23:00 | John Isner v Tommy Paul | 7-6,3-6,6-2 |
| ATP Acapulco | 2020/02/26 23:40 | John Isner v Marcos Giron | 6-3,7-6 |
Away History
| ATP New York | 2020/08/23 21:15 | Kevin Anderson v Stefanos Tsitsipas | 1-6,3-6 |
| Davis Cup | 2020/03/07 04:55 | Jeson Patrombon v Stefanos Tsitsipas | 2-6,1-6 |
| Davis Cup | 2020/03/06 03:00 | Alberto Lim v Stefanos Tsitsipas | 2-6,1-6 |
| ATP Dubai | 2020/02/29 15:00 | Novak Djokovic v Stefanos Tsitsipas | 6-3,6-4 |
| ATP Dubai | 2020/02/28 13:00 | Daniel Evans v Stefanos Tsitsipas | 2-6,3-6 |
| ATP Dubai | 2020/02/27 13:30 | Jan-Lennard Struff v Stefanos Tsitsipas | 6-4,4-6,4-6 |
| ATP Dubai | 2020/02/26 12:00 | Alexander Bublik v Stefanos Tsitsipas | 6-7,4-6 |
| ATP Dubai | 2020/02/25 15:50 | Pablo Carreno Busta v Stefanos Tsitsipas | 6-7,1-6 |
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