[10] Duke 31-23 Northwestern [1] 2022-09-10 16:00
Stadium: Ryan Field Round: 1
Home Manager: Pat Fitzgerald Away Manager: Mike Elko
Head to Head
| NCAAF | 2021/09/18 20:00 | Northwestern v Duke | W | 23-30 |
| NCAAF | 2018/09/08 16:00 | Duke v Northwestern | W | 21-7 |
| NCAAF | 2017/09/09 16:00 | Northwestern v Duke | W | 17-41 |
| NCAAF | 2016/09/18 00:00 | Northwestern v Duke | L | 24-13 |
| NCAAF | 2015/09/19 16:30 | Duke v Northwestern | L | 10-19 |
| NCAAF | 2008/09/06 12:00 | Duke v Northwestern | L | 20-24 |
| NCAAF | 2007/09/15 12:00 | Northwestern v Duke | W | 14-20 |
| NCAAF | 2003/09/20 12:00 | Duke v Northwestern | L | 10-28 |
| NCAAF | 2002/09/14 12:00 | Northwestern v Duke | L | 26-21 |
| NCAAF | 2001/09/22 12:00 | Duke v Northwestern | L | 7-44 |
| NCAAF | 2000/09/09 12:00 | Northwestern v Duke | L | 38-5 |
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