[10] Duke 31-23 Northwestern [1] 2022-09-10 16:00
Stadium: Ryan Field Round: 1
Home Manager: Pat Fitzgerald Away Manager: Mike Elko
Head to Head
| NCAAF | 2021/09/18 20:00 | Northwestern v Duke | W | 23-30 |
| NCAAF | 2018/09/08 16:00 | Duke v Northwestern | W | 21-7 |
| NCAAF | 2017/09/09 16:00 | Northwestern v Duke | W | 17-41 |
| NCAAF | 2016/09/18 00:00 | Northwestern v Duke | L | 24-13 |
| NCAAF | 2015/09/19 16:30 | Duke v Northwestern | L | 10-19 |
| NCAAF | 2008/09/06 12:00 | Duke v Northwestern | L | 20-24 |
| NCAAF | 2007/09/15 12:00 | Northwestern v Duke | W | 14-20 |
| NCAAF | 2003/09/20 12:00 | Duke v Northwestern | L | 10-28 |
Home History
| NCAAF | 2022/09/02 23:30 | Temple v Duke | W | 0-30 |
| NCAAF | 2021/11/27 17:30 | Miami Florida v Duke | L | 47-10 |
| NCAAF | 2021/11/19 00:30 | Louisville v Duke | L | 62-22 |
| NCAAF | 2021/11/13 20:30 | Duke v Virginia Tech | L | 17-48 |
| NCAAF | 2021/11/06 16:00 | Pittsburgh v Duke | L | 54-29 |
| NCAAF | 2021/10/30 20:00 | Duke v Wake Forest | L | 7-45 |
| NCAAF | 2021/10/16 16:30 | Duke v Virginia | L | 0-48 |
| NCAAF | 2021/10/09 16:30 | Georgia Tech v Duke | L | 31-27 |
Away History
| NCAAF | 2022/08/27 16:30 | Northwestern v Nebraska | W | 31-28 |
| NCAAF | 2021/11/27 20:30 | Northwestern v Illinois | L | 14-47 |
| NCAAF | 2021/11/20 17:00 | Purdue v Northwestern | L | 32-14 |
| NCAAF | 2021/11/13 17:00 | Northwestern v Wisconsin | L | 7-35 |
| NCAAF | 2021/11/06 23:00 | Iowa v Northwestern | L | 17-12 |
| NCAAF | 2021/10/30 19:30 | Minnesota v Northwestern | L | 41-14 |
| NCAAF | 2021/10/23 16:00 | Northwestern v Michigan | L | 7-33 |
| NCAAF | 2021/10/16 16:00 | Rutgers v Northwestern | W | 7-21 |
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