Head to Head
| NCAAF | 2022/11/12 20:30 | Louisville v Clemson | W | 16-31 |
| NCAAF | 2021/11/06 23:30 | Clemson v Louisville | W | 30-24 |
| NCAAF | 2019/10/19 16:00 | Clemson v Louisville | W | 45-10 |
| NCAAF | 2018/11/03 16:00 | Louisville v Clemson | W | 16-77 |
| NCAAF | 2017/09/17 00:00 | Clemson v Louisville | W | 47-21 |
| NCAAF | 2016/10/02 00:00 | Louisville v Clemson | W | 36-42 |
| NCAAF | 2015/09/17 23:30 | Louisville v Clemson | W | 17-20 |
| NCAAF | 2014/10/11 19:30 | Clemson v Louisville | W | 23-17 |
Home History
| NCAAF - Bowl Games | 2023/12/29 17:00 | Clemson v Kentucky | W | 38-35 |
| NCAAF | 2023/11/26 00:30 | Clemson v South Carolina | W | 16-7 |
| NCAAF | 2023/11/18 20:30 | North Carolina v Clemson | W | 20-31 |
| NCAAF | 2023/11/11 17:00 | Georgia Tech v Clemson | W | 21-42 |
| NCAAF | 2023/11/04 16:00 | Notre Dame v Clemson | W | 23-31 |
| NCAAF | 2023/10/28 18:00 | Clemson v NC State | L | 17-24 |
| NCAAF | 2023/10/22 00:00 | Clemson v Miami Florida | L | 20-28 |
| NCAAF | 2023/10/07 19:30 | Wake Forest v Clemson | W | 12-17 |
Away History
| NCAAF - Bowl Games | 2023/12/28 01:00 | Louisville v USC | L | 28-42 |
| NCAAF | 2023/12/03 01:00 | Louisville v Florida State | L | 6-16 |
| NCAAF | 2023/11/25 17:00 | Kentucky v Louisville | L | 38-31 |
| NCAAF | 2023/11/18 17:00 | Louisville v Miami Florida | W | 38-31 |
| NCAAF | 2023/11/10 00:30 | Virginia v Louisville | W | 24-31 |
| NCAAF | 2023/11/04 19:30 | Virginia Tech v Louisville | W | 3-34 |
| NCAAF | 2023/10/28 19:30 | Duke v Louisville | W | 0-23 |
| NCAAF | 2023/10/14 22:30 | Louisville v Pittsburgh | L | 21-38 |
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