Stadium: Center Parc Stadium Round: 1
Home Manager: Oliver Pough Away Manager: T.C. Taylor
| NCAAF - Bowl Games | 2021/12/18 17:00 | South Carolina State v Jackson State | W | 31-10 |
| NCAAF | 2022/11/19 18:30 | Norfolk State v South Carolina State | L | 42-38 |
| NCAAF | 2022/11/12 18:00 | South Carolina State v Howard | L | 14-28 |
| NCAAF | 2022/11/05 17:30 | Delaware State v South Carolina State | L | 27-24 |
| NCAAF | 2022/10/29 16:00 | South Carolina State v Morgan State | L | 14-41 |
| NCAAF | 2022/10/22 17:30 | North Carolina Central v South Carolina State | W | 24-26 |
| NCAAF | 2022/10/15 17:30 | South Carolina State v Lynchburg Dragons | W | 36-0 |
| NCAAF | 2022/10/08 18:00 | Florida A&M v South Carolina State | L | 20-14 |
| NCAAF | 2022/09/29 23:00 | South Carolina State v South Carolina | L | 10-50 |
| NCAAF - Bowl Games | 2022/12/17 17:00 | Jackson State v North Carolina Central | L | 34-41 |
| NCAAF | 2022/12/03 21:00 | Southern v Jackson State | W | 24-43 |
| NCAAF | 2022/11/19 20:00 | Jackson State v Alcorn State | W | 24-13 |
| NCAAF | 2022/11/12 22:00 | Alabama v Jackson State | W | 13-27 |
| NCAAF | 2022/11/05 23:00 | Jackson State v Texas Southern Tigers | W | 41-14 |
| NCAAF | 2022/10/29 18:00 | Southern v Jackson State | W | 0-35 |
| NCAAF | 2022/10/22 19:00 | Campbell v Jackson State | W | 14-22 |
| NCAAF | 2022/10/15 20:00 | Jackson State v Bethune Cookman | W | 48-8 |