[7] Wake Forest 21-48 Louisville [14] 2022-10-29 19:30
Stadium: L&N Federal Credit Union Stadium Round: 1
Home Manager: Scott Satterfield Away Manager: Dave Clawson
Head to Head
| NCAAF | 2021/10/02 16:30 | Louisville v Wake Forest | W | 34-37 |
| NCAAF | 2020/12/12 17:00 | Wake Forest v Louisville | L | 21-45 |
| NCAAF | 2019/10/12 23:30 | Louisville v Wake Forest | L | 62-59 |
| NCAAF | 2018/10/27 16:00 | Wake Forest v Louisville | W | 56-35 |
| NCAAF | 2017/10/28 16:20 | Louisville v Wake Forest | W | 32-42 |
| NCAAF | 2016/11/13 00:00 | Wake Forest v Louisville | L | 12-44 |
| NCAAF | 2015/10/30 23:00 | Wake Forest v Louisville | L | 19-20 |
| NCAAF | 2014/09/27 19:30 | Louisville v Wake Forest | L | 20-10 |
Home History
| NCAAF | 2022/10/22 19:30 | Boston College v Wake Forest | W | 15-43 |
| NCAAF | 2022/10/08 23:30 | Army v Wake Forest | W | 10-45 |
| NCAAF | 2022/10/01 19:30 | Wake Forest v Florida State | W | 31-21 |
| NCAAF | 2022/09/24 16:00 | Clemson v Wake Forest | L | 51-45 |
| NCAAF | 2022/09/17 21:00 | Liberty v Wake Forest | W | 36-37 |
| NCAAF | 2022/09/10 16:00 | Wake Forest v Vanderbilt | W | 45-25 |
| NCAAF | 2022/09/01 23:30 | VMI v Wake Forest | W | 10-44 |
| NCAAF - Bowl Games | 2021/12/31 16:00 | Rutgers v Wake Forest | W | 10-38 |
Away History
| NCAAF | 2022/10/23 00:00 | Pittsburgh v Louisville | W | 10-24 |
| NCAAF | 2022/10/08 16:00 | Louisville v Virginia | W | 34-17 |
| NCAAF | 2022/10/01 16:00 | Louisville v Boston College | L | 33-34 |
| NCAAF | 2022/09/24 16:00 | South Florida v Louisville | W | 3-41 |
| NCAAF | 2022/09/16 23:30 | Florida State v Louisville | L | 35-31 |
| NCAAF | 2022/09/09 23:30 | Louisville v Central Florida | W | 20-14 |
| NCAAF | 2022/09/04 00:00 | Louisville v Syracuse | L | 7-31 |
| NCAAF - Bowl Games | 2021/12/28 20:15 | Louisville v Air Force | L | 28-31 |
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