[10] Wake Forest 27-48 Clemson [35] 2021-11-20 17:00
Stadium: Memorial Stadium Round: 1
Home Manager: Dabo Swinney Away Manager: Dave Clawson
Head to Head
| NCAAF | 2020/09/12 23:30 | Clemson v Wake Forest | L | 37-13 |
| NCAAF | 2019/11/16 20:30 | Wake Forest v Clemson | L | 3-52 |
| NCAAF | 2018/10/06 19:30 | Clemson v Wake Forest | L | 63-3 |
| NCAAF | 2017/10/07 16:00 | Wake Forest v Clemson | L | 14-28 |
| NCAAF | 2016/11/20 00:00 | Clemson v Wake Forest | L | 35-13 |
| NCAAF | 2015/11/21 20:30 | Clemson v Wake Forest | L | 33-13 |
| NCAAF | 2014/11/07 00:30 | Wake Forest v Clemson | L | 20-34 |
| NCAAF | 2012/10/25 12:00 | Wake Forest v Clemson | L | 13-42 |
Home History
| NCAAF | 2021/11/14 00:30 | NC State v Wake Forest | W | 42-45 |
| NCAAF | 2021/11/06 16:00 | Wake Forest v North Carolina | L | 55-58 |
| NCAAF | 2021/10/30 20:00 | Duke v Wake Forest | W | 7-45 |
| NCAAF | 2021/10/23 16:00 | Wake Forest v Army | W | 70-56 |
| NCAAF | 2021/10/09 19:30 | Wake Forest v Syracuse | W | 40-37 |
| NCAAF | 2021/10/02 16:30 | Louisville v Wake Forest | W | 34-37 |
| NCAAF | 2021/09/24 23:00 | Wake Forest v Virginia | W | 37-17 |
| NCAAF | 2021/09/18 19:30 | Florida State v Wake Forest | W | 14-35 |
Away History
| NCAAF | 2021/11/13 17:00 | Connecticut v Clemson | W | 7-44 |
| NCAAF | 2021/11/06 23:30 | Clemson v Louisville | W | 30-24 |
| NCAAF | 2021/10/30 19:30 | Florida State v Clemson | W | 20-30 |
| NCAAF | 2021/10/23 19:30 | Clemson v Pittsburgh | L | 17-27 |
| NCAAF | 2021/10/15 23:00 | Clemson v Syracuse | W | 17-14 |
| NCAAF | 2021/10/02 23:30 | Boston College v Clemson | W | 13-19 |
| NCAAF | 2021/09/25 19:30 | Clemson v NC State | L | 21-27 |
| NCAAF | 2021/09/18 19:30 | Georgia Tech v Clemson | W | 8-14 |
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