[65] Louisville 62-22 Duke [105] 2021-11-19 00:30
Stadium: Brooks Field at Wallace Wade Stadium Round: 1
Home Manager: David Cutcliffe Away Manager: Scott Satterfield
Head to Head
| NCAAF | 2016/10/14 23:00 | Duke v Louisville | W | 14-24 |
| NCAAF | 2002/09/07 12:00 | Duke v Louisville | W | 3-40 |
Home History
| NCAAF | 2021/11/13 17:00 | Syracuse v Louisville | W | 3-41 |
| NCAAF | 2021/11/06 23:30 | Clemson v Louisville | L | 30-24 |
| NCAAF | 2021/10/30 23:30 | Louisville v NC State | L | 13-28 |
| NCAAF | 2021/10/23 20:00 | Boston College v Louisville | W | 14-28 |
| NCAAF | 2021/10/09 19:00 | Virginia v Louisville | L | 34-33 |
| NCAAF | 2021/10/02 16:30 | Louisville v Wake Forest | L | 34-37 |
| NCAAF | 2021/09/25 19:30 | Louisville v Florida State | W | 31-23 |
| NCAAF | 2021/09/17 23:30 | Central Florida v Louisville | W | 35-42 |
Away History
| NCAAF | 2021/11/13 20:30 | Duke v Virginia Tech | L | 17-48 |
| NCAAF | 2021/11/06 16:00 | Pittsburgh v Duke | L | 54-29 |
| NCAAF | 2021/10/30 20:00 | Duke v Wake Forest | L | 7-45 |
| NCAAF | 2021/10/16 16:30 | Duke v Virginia | L | 0-48 |
| NCAAF | 2021/10/09 16:30 | Georgia Tech v Duke | L | 31-27 |
| NCAAF | 2021/10/02 16:00 | Duke v North Carolina | L | 7-38 |
| NCAAF | 2021/09/25 20:00 | Kansas v Duke | W | 33-52 |
| NCAAF | 2021/09/18 20:00 | Northwestern v Duke | W | 23-30 |
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