The Ukrainian Second League (Ukrainian: Друга ліга, Druha Liha) is a professional football league in Ukraine which is part of the Professional Football League of Ukraine, a collective member of the Ukrainian Association of Football. As the third tier it was established in 1992 as the Transitional League and changed its name the next season.

The league is lower than the Ukrainian First League (Persha Liha) and the lowest level of professional football competitions in the country. Since 1996 the league, after being merged with its lower tier (in 1992–1995 there was the Third League), consists of two main regions roughly north-west and south-east. The league's relegated teams lose their professional status and return to their regional associations.

Ukraina - Druha Liga er det tredje nivået i det ukrainske ligasystemet for fotball. Ligaen består av 18 lag, som spiller i en dobbel serie. De to beste lagene rykker opp til Persha Liha, mens de tre nederste lagene rykker ned til Amatorfutbolna Liha.

Den første sesongen av Druha Liga ble spilt i 1992, og siden den gang har ligaen vært dominert av lag fra de vestlige og sentrale delene av Ukraina. De mest suksessfulle lagene i ligaens historie er FC Nyva Ternopil og FC Volyn Lutsk, som begge har vunnet ligaen to ganger.

I sesongen 2022/23 består Druha Liga av følgende lag:

* Ahrobisvit Vikna
* Bukovyna Chernivtsi
* Dinaz Vyshhorod
* FC Cherkasy
* FC Chernihiv
* FC Kalush
* FC Lviv
* FC Mynai
* FC Nyva Ternopil
* FC Polissya Zhytomyr
* FC Ternopil
* FC Volyn Lutsk
* Karpaty Lviv
* Kolos Kovalivka
* Metalist Kharkiv
* Nyva Vinnytsia
* Prykarpattia Ivano-Frankivsk
* Skala Stryi